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张佳佳博士学术报告

  发布日期:2017-06-30  浏览量:462


报告题目: Computationally Efficient Estimation for the Generalized Odds Rate Mixture Cure Model with Interval Censored Data

: 张佳佳博士(美国南卡罗来纳大学副教授,终身职位)

报告时间: 201774(周二)  16:00-17:00

报告地点: 磬苑校区澳门赌搏网站大全H306

报告摘要:For semiparametric survival models with interval censored data and a cure fraction, it is often difficult to derive nonparametric maximum likelihood estimation due to the challenge in maximizing the complex likelihood function. In this paper, we propose a computationally efficient EM algorithm, facilitated by a gamma-poisson data augmentation, for maximum likelihood estimation in a class of generalized odds rate mixture cure (GORMC) models with interval censored data. The gamma-poisson data augmentation greatly simplifies the EM estimation and enhances the convergence speed of the EM algorithm. The empirical properties of the proposed method are examined through extensive simulation studies and compared with numerical maximum likelihood estimates. An R package ``GORCure" is developed to implement the proposed method and its use is illustrated by an application to the Aerobic Center Longitudinal Study dataset.

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专家概况: 张佳佳,2007年毕业于加拿大纪念大学(Memorial University),获生物统计博士学位,现任美国南卡罗来纳大学流行病与生物统计系副教授,终身职位。主要从事生存分析、半参数估计方法等方面的理论与应用研究。研究方向包括生存模型、空间生存模型、混合治愈模型、脆弱模型、样本容量计算等。张佳佳博士在国际核心统计学学术期刊上发表论文百余篇,如Mayo Clinic ProceedingsCirculationNutrition ReviewsThe Journal of NutritionJournal of NutritionAmerican Journal of MedicineMolecular NeurobiologyAmerican Journal of EpidemiologyClinical NutritionScientific ReportBritish Journal of CancerCancer Epidemiology Biomarkers & PreventionJournal of Biomedical NanotechnologyJournal of ImmunologyCancer Causes and ControlBiometrkaBiometricsAnnals of Applied StatisticsStatistica SinicaJournal of Applied StatisticsBiometrical JournalLifetime Data AnalysisStatistical Methods in Medical ResearchComputational Statistics and Data AnalysisStatistics in MedicineJournal of Statistical Planning and Inference等。主持美国卫生研究院(National Institutes of Health)项目5项。多次在国际学术会议作邀请报告及担任国际会议分会主席。担任国际学术期刊Journal of Biometrics & BiostatisticsNeurosurgery编委,多种国际核心学术期刊的审稿人,美国统计学会、中国国际统计学会、加拿大统计协会会员。

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